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PHD2-IN-4

PHD2 Inhibitor

PHD2-IN-4 is a selective inhibitor of prolyl hydroxylase domain 2 (PHD2), exhibiting an IC50 of 4 nM. It serves as a valuable tool for investigating pathways related to hypoxia signaling and is particularly relevant for research in chronic kidney disease. This compound facilitates the study of PHD2's role in cellular responses to oxygen levels, advancing our understanding of related pathological conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2924181-60-0
Applications	PHD2 Inhibitor
Formula	C₂₁H₁₉N₅O₃
Molecular Weight	389.41
SMILES	O=C(C1=C(O)C2=C(C=N1)N=C(C=C2)N3CCOCC3)NCC4=CC=C(C#N)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.