Fig. 1 · Structure
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Phelorphan
DNA/RNA Synthesi
Phelorphan is a purine MTH1 inhibitor that engages the cellular MTH1 enzyme, primarily involved in the synthesis of DNA and RNA. While its cytotoxic effects on cancer cells are comparatively lower than those of other MTH1 inhibitors, it serves important functions in studying the role of MTH1 in cellular metabolism and potential off-target effects. Phelorphan is a valuable tool for researchers investigating the mechanisms of cancer cell survival and therapeutic strategies associated with MTH1 modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 110871-16-4 |
| Applications | DNA/RNA Synthesi |
| Formula | C20H22N2O4S |
| Molecular Weight | 386.46 |
| SMILES | O=C([C@@H](NC([C@@H](NC(CS)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.