Fig. 1 · Structure
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Phenformin
Antidiabetic/Antitumor Agent
Phenformin, a biguanide hypoglycemic agent, primarily targets mitochondrial respiratory chain complex I. This inhibition results in an increased AMP/ATP ratio, activating AMP-activated protein kinase (AMPK) and subsequently suppressing the mTOR pathway, which leads to reduced cell proliferation and promotes apoptosis and autophagy. Additionally, phenformin has shown effectiveness in inhibiting cancer stem cells (CSCs) and demonstrates promising antitumor activity, making it a valuable compound for research in metabolic disorders and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 114-86-3 |
| Applications | Antidiabetic/Antitumor Agent |
| Formula | C10H15N5 |
| Molecular Weight | 205.26 |
| Synonyms | Phenethylbiguanide |
| SMILES | NC(NC(NCCC1=CC=CC=C1)=N)=N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.