Phorone, a glutathione (GSH) depletor, functions by specifically and reversibly depleting free GSH through enzymatic interaction with glutathione S-transferase (Km = 0.9 mM). This compound has been demonstrated to reversibly affect the binding and nuclear uptake of glucocorticoid receptors in rat liver, correlating with fluctuations in GSH levels. Phorone is valuable for research focused on liver toxicity mechanisms and the role of oxidative stress in cellular dysfunction.
Phorone, a glutathione (GSH) depletor, functions by specifically and reversibly depleting free GSH through enzymatic interaction with glutathione S-transferase (Km = 0.9 mM). This compound has been demonstrated to reversibly affect the binding and nuclear uptake of glucocorticoid receptors in rat liver, correlating with fluctuations in GSH levels. Phorone is valuable for research focused on liver toxicity mechanisms and the role of oxidative stress in cellular dysfunction.
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