Fig. 1 · Structure
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Phosphoramidon
Metalloprotease Inhibitor
Phosphoramidon is a selective inhibitor of metalloproteases, primarily targeting thermolysin with an IC50 of 0.4 μg/mL. In addition to its activity against thermolysin, Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE), with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively. This compound is widely utilized in research exploring the modulation of proteolytic pathways and their implications in various physiological and pathological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 36357-77-4 |
| Applications | Metalloprotease Inhibitor |
| Formula | C23H34N3O10P |
| Molecular Weight | 543.50 |
| SMILES | O[C@H]([C@@H]([C@H]([C@@H](O1)C)O)O)[C@@H]1OP(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.