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Biological Activity
PHTPP is a pyrazolo[1,5-α]pyrimidine-based ligand that acts as a full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα.
| In vitro | DMSO | 49 mg/mL (115.75 mM) | |
| Water | Insoluble | ||
| Ethanol | 82 mg/mL (193.71 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.62 mL | 118.12 mL | 236.24 mL |
| 0.5 mM | 4.72 mL | 23.62 mL | 47.25 mL |
| 1 mM | 2.36 mL | 11.81 mL | 23.62 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 423.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17035 |
|---|---|
| Actions | Antagonist |
| CAS No. | 805239-56-9 |
| Formula | C20H11F6N3O |
| M. Wt | 423.3 |
| Purity | >98% |
| SMILES | OC(C=C1)=CC=C1C(C(C2=CC=CC=C2)=N3)=C4N3C(C(F)(F)F)=CC(C(F)(F)F)=N4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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