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PI3K-IN-10

Catalog No.: A79887
PI3K Inhibitor
PI3K-IN-10 is a potent pan-PI3K inhibitor derived from benzimidazole. This compound selectively targets the phosphoinositide 3-kinase (PI3K) pathway, demonstrating significant inhibitory activity across various PI3K isoforms. Its key biological activity makes it a valuable tool for investigating PI3K-related signaling mechanisms and potential therapeutic applications in cancer and metabolic disorders.
PI3K-IN-10 2211922-64-2 PI3K Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPI3K-IN-10 is a potent pan-PI3K inhibitor derived from benzimidazole. This compound selectively targets the phosphoinositide 3-kinase (PI3K) pathway, demonstrating significant inhibitory activity across various PI3K isoforms. Its key biological activity makes it a valuable tool for investigating PI3K-related signaling mechanisms and potential therapeutic applications in cancer and metabolic disorders.
Product Information
Catalog NumA79887
FormulaC23H19ClN6O
Molecular Weight430.89
CAS Number2211922-64-2
SMILESClC1=CC=CC(C1=NC=C2)=C2N(C=N3)C4=C3C(C5=CNC=N5)=CC(N6CCOCC6)=C4
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PI3K/Akt/mTOR > PI3K