PI3Kδ-IN-16 is a highly selective inhibitor of the PI3Kδ isoform, displaying an impressive IC50 value of 0.9 nM. This compound exhibits significant anti-proliferative effects on SU-DHL-6 cells, leading to cell cycle arrest and the induction of apoptosis. PI3Kδ-IN-16 demonstrates substantial selectivity for PI3Kδ over other isoforms, with a kinase activity that is approximately 378-fold greater than PI3Kα, 412-fold greater than PI3Kβ, and 10-fold greater than PI3Kγ. It is a valuable tool for research into hematologic malignancies and the therapeutic targeting of PI3Kδ.
PI3Kδ-IN-16 is a highly selective inhibitor of the PI3Kδ isoform, displaying an impressive IC50 value of 0.9 nM. This compound exhibits significant anti-proliferative effects on SU-DHL-6 cells, leading to cell cycle arrest and the induction of apoptosis. PI3Kδ-IN-16 demonstrates substantial selectivity for PI3Kδ over other isoforms, with a kinase activity that is approximately 378-fold greater than PI3Kα, 412-fold greater than PI3Kβ, and 10-fold greater than PI3Kγ. It is a valuable tool for research into hematologic malignancies and the therapeutic targeting of PI3Kδ.
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