PI4K-IN-1 is a potent inhibitor of phosphatidylinositol 4-kinase III (PI4KIII) isoforms, exhibiting pIC50 values of 9.0 for PI4KIIIα and 6.6 for PI4KIIIβ. In addition, it demonstrates inhibitory activity against PI3K isoforms α, β, γ, and δ, with pIC50 values of 4.0, <3.7, 5.0, and <4.1, respectively. This compound is valuable for research applications focused on dissecting signaling pathways involving phosphoinositides and investigating potential therapeutic targets in cancer and metabolic disorders.
Fig. 1 · Structure
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PI4K-IN-1
PI4K Inhibitor
PI4K-IN-1 is a potent inhibitor of phosphatidylinositol 4-kinase III (PI4KIII) isoforms, exhibiting pIC50 values of 9.0 for PI4KIIIα and 6.6 for PI4KIIIβ. In addition, it demonstrates inhibitory activity against PI3K isoforms α, β, γ, and δ, with pIC50 values of 4.0, <3.7, 5.0, and <4.1, respectively. This compound is valuable for research applications focused on dissecting signaling pathways involving phosphoinositides and investigating potential therapeutic targets in cancer and metabolic disorders.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1800017-49-5 |
| Applications | PI4K Inhibitor |
| Formula | C24H27N3O3S |
| Molecular Weight | 437.55 |
| SMILES | OC([C@@H](CC1)CC[C@H]1CNC2=NC3=CC=C(C4=CC(N(CC5CC5)C=C4)=O)C=C3S2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.