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PI4KIII beta inhibitor 5

PI4KIIIβ Inhibitor

PI4KIII beta inhibitor 5 is a selective inhibitor of PI4KIIIβ with an IC50 of 19 nM. This compound effectively induces apoptosis and causes cell cycle arrest at the G2/M phase, while also promoting autophagy through the inhibition of the PI3K/AKT signaling pathway. Notably, PI4KIII beta inhibitor 5 exhibits significant antitumor activity in the H446 xenograft model of small cell lung cancer, making it a valuable tool for research in cancer therapy.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3029506-23-5
Applications	PI4KIIIβ Inhibitor
Formula	C₂₄H₂₇F₂N₃O₄S₂
Molecular Weight	523.62
SMILES	O=S(C1=C(C=CC(C2=C(N=C(S2)NC(CCCCC)=O)C)=C1)OC)(NCC3=C(C=C(C=C3)F)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.