PI5P4Ks-IN-2 is a selective inhibitor of phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kγ). It demonstrates inhibitory activity against various PI5P4K isoforms, exhibiting pIC50 values of <4.3 for PI5P4Kα, <4.6 for PI5P4Kβ, 6.2 for PI5P4Kγ, and 0.32 for PI5P4Kγ+. This compound is valuable for studying the role of PI5P4K in cellular signaling and its implications in diseases such as cancer and metabolic disorders.
Fig. 1 · Structure
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PI5P4Ks-IN-2
PI5P4K Inhibitor
PI5P4Ks-IN-2 is a selective inhibitor of phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kγ). It demonstrates inhibitory activity against various PI5P4K isoforms, exhibiting pIC50 values of <4.3 for PI5P4Kα, <4.6 for PI5P4Kβ, 6.2 for PI5P4Kγ, and 0.32 for PI5P4Kγ+. This compound is valuable for studying the role of PI5P4K in cellular signaling and its implications in diseases such as cancer and metabolic disorders.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2766854-03-7 |
| Applications | PI5P4K Inhibitor |
| Formula | C22H23N5 |
| Molecular Weight | 357.45 |
| SMILES | CN1C=CC2=C1C(NCC3=NC=CC=C3)=NC(C4=CC=CC=C4C(C)C)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.