Fig. 1 · Structure
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Picolinafen
PDS Inhibitor
Picolinafen is a pyridine-class herbicide that functions as a phytoene desaturase (PDS) inhibitor. It effectively controls broadleaf weeds by disrupting carotenoid biosynthesis, leading to cytotoxic effects in porcine trophectoderm (pTr) and luminal epithelial (pLE) cells. Picolinafen induces the accumulation of reactive oxygen species (ROS), calcium depletion, and activates MAPK and PI3K signaling pathways, resulting in decreased cell viability, increased apoptosis, impaired migration, and altered expression of implantation-related genes. Additionally, it demonstrates toxicity during zebrafish embryogenesis, with an LD50 value of 2.7 mg/kg in mammals and 7 μg/L in aquatic organisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 137641-05-5 |
| Applications | PDS Inhibitor |
| Formula | C19H12F4N2O2 |
| Molecular Weight | 376.30 |
| Synonyms | AC 900001 |
| SMILES | O=C(C1=NC(OC2=CC(C(F)(F)F)=CC=C2)=CC=C1)NC3=CC=C(C=C3)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.