PIK5-12d

Name: PIK5-12d
Brand: Adooq Bioscience
SKU: A23946
Rating: 5 (288 reviews)

Catalog No.: A23946

PROTAC PIKfyve degrade

PIK5-12d is a potent PROTAC degrader targeting PIKfyve, with a DC₅₀ of 1.48 nM. It induces extensive cytoplasmic vacuolization, disrupts autophagic flux, and inhibits proliferation in multiple prostate cancer cell lines. PIK5-12d exhibits notable anti-tumor activity, supporting its use in cancer research.

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PIK5-12d 3036457-38-9 PROTAC PIKfyve degrade

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Grouped product items
Size	Price	Stock
1mg	$225.00	In stock
5mg	$480.00	In stock
10mg	$780.00	In stock
50mg	$2,480.00	In stock
Bulk Size	Bulk Discount

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Research use only. We do not sell to patients.

Data Sheet SDS

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Biological Activity

Description	PIK5-12d is a potent PROTAC degrader targeting PIKfyve, with a DC₅₀ of 1.48 nM. It induces extensive cytoplasmic vacuolization, disrupts autophagic flux, and inhibits proliferation in multiple prostate cancer cell lines. PIK5-12d exhibits notable anti-tumor activity, supporting its use in cancer research.

Product Information

Catalog Num	A23946
Formula	C52H64N10O7S
Molecular Weight	973.19
CAS Number	3036457-38-9
SMILES	CC1=CC=CC(/C=N/NC2=NC(OCCC3=CC=C(NC(CCCCC(N[C@H](C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C=C5)C6=C(N=CS6)C)=O)=O)C(C)(C)C)=O)=O)C=C3)=NC(N7CCOCC7)=C2)=C1
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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