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PIN1 degrader-1

Pin1 Degrader

PIN1 Degrader-1 is a selective inhibitor of the proline cis-trans isomerase Pin1, exhibiting an IC50 of 21.5 nM. This compound forms a covalent bond with Cys113, inducing conformational changes that destabilize the protein and promote proteasome-dependent degradation. PIN1 Degrader-1 effectively decreases cell viability in various cancer cell lines, making it a valuable tool for cancer research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3080918-50-6
Applications	Pin1 Degrader
Formula	C₃₀H₃₂Cl₂N₆O₄
Molecular Weight	611.52
SMILES	NC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@@H]3CCCCN3C([C@H](CC4=CNC5=C4C=CC(Cl)=C5)NC(CCl)=O)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.