Fig. 1 · Structure
Documents & Downloads
Pinokalant
Cation Channel Blocker
Pinokalant is a non-selective cation channel blocker that has demonstrated significant effects on cerebral ischemia. In preclinical studies, Pinokalant reduces cortical infarct volume and enhances the metabolic and electrophysiological status of the ischemic penumbra following middle cerebral artery occlusion in rodents. Additionally, it decreases lesion size observed on magnetic resonance imaging during the acute phase of ischemic stroke. This compound may also have potential applications in researching anti-SARS-CoV-2 activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 149759-26-2 |
| Applications | Cation Channel Blocker |
| Formula | C41H48N2O9 |
| Molecular Weight | 712.83 |
| Synonyms | LOE-908 |
| SMILES | O=C(C(C1=NCCC2=C1C=C(C(OC)=C2)OC)C3=CC=CC=C3)N(CCC4=CC=C(C(OC)=C4OC)OC)CCC5=CC=C(C(OC)=C5OC)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.