Fig. 1 · Structure
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PIP-199
RMI-MM2 Interaction Inhibitor
PIP-199 is a selective inhibitor of the RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, exhibiting an IC50 of 36 μM. This compound demonstrates potential in enhancing the sensitivity of resistant tumors to DNA crosslinking chemotherapeutics. PIP-199 is a valuable tool for researching mechanisms of genome stability and therapeutic resistance in cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 622795-76-0 |
| Applications | RMI-MM2 Interaction Inhibitor |
| Formula | C27H28N4O3 |
| Molecular Weight | 456.54 |
| SMILES | O=C(N1CCN(C(C2=C(C3=CC=CC=C3)N(O)C4=C2C=CC=C4)C5=NC=CC=C5)CC1)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.