Fig. 1 · Structure
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Pipernonaline
Anti-prostate cancer Agent
Pipernonaline is a piperine derivative that acts as an anti-prostate cancer agent. It effectively inhibits the proliferation of both androgen-dependent and androgen-independent LNCaP and PC-3 prostate cancer cells. The compound induces apoptosis by activating caspase-3 and promoting the cleavage of procaspase-3 and PARP. Additionally, Pipernonaline mediates the production of reactive oxygen species (ROS), increases intracellular calcium levels, and causes mitochondrial membrane depolarization, highlighting its potential for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 88660-10-0 |
| Applications | Anti-prostate cancer Agent |
| Formula | C21H27NO3 |
| Molecular Weight | 341.44 |
| SMILES | O=C(N1CCCCC1)/C=C/CCCC/C=C/C2=CC=C(OCO3)C3=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.