Fig. 1 · Structure
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PK-THPP
TASK-3 Blocker
PK-THPP is a selective blocker of the TASK-3 potassium ion channel (K2P9.1), exhibiting IC50 values of 35 nM for TASK-3 and 300 nM for TASK-1. This compound demonstrates minimal activity against other potassium channels, making it a valuable tool for investigating specific ion channel functions. PK-THPP is recognized for its efficacy as a breathing stimulant and is useful for research into various breathing disorders and related physiological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 1332454-07-5 |
| Applications | TASK-3 Blocker |
| Formula | C29H32N4O2 |
| Molecular Weight | 468.59 |
| SMILES | O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N3CC4=C(N5CCC(C(CCC)=O)CC5)N=CN=C4CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.