Fig. 1 · Structure
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PKC/PKD-IN-1
PKC/PKD Inhibitor
PKC/PKD-IN-1 is a potent dual inhibitor of protein kinase C and protein kinase D, exhibiting an IC50 of 0.6 nM against PKD1. This compound demonstrates the ability to mitigate cardiac hypertrophy induced by high-salt diets, making it a valuable tool for investigating mechanisms related to heart failure. Its specificity and efficacy position it as a significant reagent for researchers focused on cardiac disease and kinase signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1071135-06-2 |
| Applications | PKC/PKD Inhibitor |
| Formula | C23H28N6 |
| Molecular Weight | 388.51 |
| SMILES | C1(NC2CCCCC2)=NC=CC(C3=CC4=C(C(N5CCNCC5)=N3)C=CN=C4)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.