Fig. 1 · Structure
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PKM2 agonist-1
Cat. No.
A77428
CAS
3075162-42-1
PKM2 Agonist
PKM2 agonist-1 is an allosteric activator of pyruvate kinase M2 (PKM2) with a reported AC50 of 77 nM. This compound has been shown to inhibit angiotensin II-induced phenotypic switching in smooth muscle cells, demonstrating significant biological activity in vascular biology. Additionally, PKM2 agonist-1 effectively reduces the incidence of aortic dissection and associated mortality, making it a valuable tool for research in cardiovascular disease and cellular metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 3075162-42-1 |
| Applications | PKM2 Agonist |
| Formula | C24H23N5O4S2 |
| Molecular Weight | 509.60 |
| SMILES | O=S(NC1=CC=C(C=C1)C2=NC=CN2C3CN(C3)S(=O)(C4CC4)=O)(C5=CC=CC6=CC=CN=C65)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.