PKM2 agonist-1 is an allosteric activator of pyruvate kinase M2 (PKM2) with a reported AC50 of 77 nM. This compound has been shown to inhibit angiotensin II-induced phenotypic switching in smooth muscle cells, demonstrating significant biological activity in vascular biology. Additionally, PKM2 agonist-1 effectively reduces the incidence of aortic dissection and associated mortality, making it a valuable tool for research in cardiovascular disease and cellular metabolism.
PKM2 agonist-1 is an allosteric activator of pyruvate kinase M2 (PKM2) with a reported AC50 of 77 nM. This compound has been shown to inhibit angiotensin II-induced phenotypic switching in smooth muscle cells, demonstrating significant biological activity in vascular biology. Additionally, PKM2 agonist-1 effectively reduces the incidence of aortic dissection and associated mortality, making it a valuable tool for research in cardiovascular disease and cellular metabolism.
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