PKRA83 is a potent antagonist of prokineticin 2 (PK2), functioning by competing for binding sites on PKR1 and PKR2 receptors. It demonstrates significant inhibition of PK2, with IC50 values of 5.0 nM for PKR1 and 8.2 nM for PKR2. PKRA83 exhibits various biological activities, including anticancer, anti-arthritis, and anti-angiogenic effects, making it valuable for research applications in cancer biology, inflammatory diseases, and angiogenesis studies.
PKRA83 is a potent antagonist of prokineticin 2 (PK2), functioning by competing for binding sites on PKR1 and PKR2 receptors. It demonstrates significant inhibition of PK2, with IC50 values of 5.0 nM for PKR1 and 8.2 nM for PKR2. PKRA83 exhibits various biological activities, including anticancer, anti-arthritis, and anti-angiogenic effects, making it valuable for research applications in cancer biology, inflammatory diseases, and angiogenesis studies.
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