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PLK1-IN-15

Name: PLK1-IN-15
Brand: Adooq Bioscience
SKU: A31756
Availability: OutOfStock

Cat. No. A31756 CAS 3068529-37-0

PLK1 Inhibitor

PLK1-IN-15 is a potent inhibitor of Polo-like Kinase 1 (PLK1) with an IC50 of 38.5 nM. It demonstrates significant antiproliferative effects in various cancer cell lines, including HepG2, Huh7, H1299, and A549, with IC50 values of 2.03, 2.08, 4.79, and 17.11 μM, respectively. PLK1-IN-15 is known to induce cell cycle arrest at the G2/M phase and trigger apoptosis, underscoring its potential as an effective agent in cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3068529-37-0
Applications	PLK1 Inhibitor
Formula	C₂₅H₂₉N₇O₄S
Molecular Weight	523.61
SMILES	O=C(OC)C1=C(SC2=C1CCCC2)NC3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3[N+]([O-])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.