PLX8394

Catalog No.: A16840
BRAF inhibitor
PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
Grouped product items
Product Name Price Stock Qty
PLX8394 5mg
$60.00
In stock
PLX8394 10mg
$100.00
In stock
PLX8394 50mg
$320.00
In stock
PLX8394 100mg
$520.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
Product Information
Catalog Num A16840
Formula C25H21F3N6O3S
Molecular Weight 542.53
CAS Number 1393466-87-9
SMILES O=S(N1C[C@H](F)CC1)(NC2=CC=C(F)C(C(C3=CNC4=NC=C(C5=CN=C(C6CC6)N=C5)C=C43)=O)=C2F)=O
Synonyms PLX 8394, PLX-8394
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 96 mg/mL (176.95 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.43 mL 92.16 mL 184.32 mL
0.5 mM 3.69 mL 18.43 mL 36.86 mL
1 mM 1.84 mL 9.22 mL 18.43 mL
5 mM 0.37 mL 1.84 mL 3.69 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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