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PMPA (NMDA antagonist)

Catalog No.: A67251
NMDA Receptor Antagonist
PMPA, an NMDA receptor antagonist, selectively inhibits the NMDA receptor subtypes NR2A, NR2B, NR2C, and NR2D with Ki values of 0.84, 2.74, 3.53, and 4.16 μM, respectively. This compound plays a critical role in research related to excitotoxicity and neurodegenerative diseases. Its ability to modulate synaptic transmission makes it valuable for studies investigating the pathophysiology of various neurological disorders.
PMPA (NMDA antagonist) 113919-36-1 NMDA Receptor Antagonist
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPMPA, an NMDA receptor antagonist, selectively inhibits the NMDA receptor subtypes NR2A, NR2B, NR2C, and NR2D with Ki values of 0.84, 2.74, 3.53, and 4.16 μM, respectively. This compound plays a critical role in research related to excitotoxicity and neurodegenerative diseases. Its ability to modulate synaptic transmission makes it valuable for studies investigating the pathophysiology of various neurological disorders.
Product Information
Catalog NumA67251
FormulaC6H13N2O5P
Molecular Weight224.15
CAS Number113919-36-1
SMILESO=C(C1NCCN(CP(O)(O)=O)C1)O
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Neuronal Signaling > NMDA Receptors