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PNR-3-82

EndoG Inhibitor

PNR-3-82 is a selective inhibitor of the apoptotic endonuclease G (EndoG), exhibiting an IC50 of 0.61 μM, demonstrating greater potency against EndoG compared to DNase I. This compound does not inhibit several other cell death-associated enzymes, including DNase II, RNase A, proteinase, lactate dehydrogenase, and superoxide dismutase 1. PNR-3-82 provides cytoprotective effects by preventing cell death induced by Cisplatin and Docetaxel, making it a valuable tool for research into cellular injury and apoptosis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1424353-64-9
Applications	EndoG Inhibitor
Formula	C₂₅H₁₇N₃O₄S
Molecular Weight	455.49
SMILES	O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(OC)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.