Fig. 1 · Structure
Documents & Downloads
PNU-107484A
GABAA Receptor Ligand
PNU-107484A is a selective GABAA receptor ligand with distinct activity across various α isoform subtypes. It functions as a positive allosteric modulator for the α1β2γ2 subtype, enhancing GABA-induced chloride currents, while exhibiting inhibitory effects on the α3β2γ2 and α6β2γ2 subtypes. The compound demonstrates half-maximal inhibitory concentrations of 3.1 μM for α1β2γ2, 4.2 μM for α3β2γ2, and 3.5 μM for α6β2γ2. PNU-107484A serves as a valuable tool for exploring the physiological implications of different GABAA receptor α isoform subtypes in research settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 200266-76-8 |
| Applications | GABAA Receptor Ligand |
| Formula | C18H23ClN6 |
| Molecular Weight | 358.87 |
| SMILES | CN1C2=NC(N3CCCC3)=NC(N4CCCC4)=C2C5=C1C=CN=C5.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.