PNU-142633 is a selective and orally bioavailable agonist of the 5-HT1D receptor, exhibiting a high affinity with a Ki of 6 nM for the human 5-HT1D receptor. In contrast, it demonstrates minimal interaction with the human 5-HT1B receptor, with a Ki value exceeding 18,000 nM. This compound is primarily utilized in research related to migraine therapy, showcasing its potential anti-migraine efficacy.
PNU-142633 is a selective and orally bioavailable agonist of the 5-HT1D receptor, exhibiting a high affinity with a Ki of 6 nM for the human 5-HT1D receptor. In contrast, it demonstrates minimal interaction with the human 5-HT1B receptor, with a Ki value exceeding 18,000 nM. This compound is primarily utilized in research related to migraine therapy, showcasing its potential anti-migraine efficacy.
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