Fig. 1 · Structure
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PNU-145156E
Angiogenesis Inhibitor
PNU-145156E is an angiogenesis inhibitor that exhibits anti-tumor activity by targeting the binding of basic fibroblast growth factor (bFGF) to its receptor. It effectively impedes bFGF-induced proliferation and motility of endothelial cells, making it a valuable reagent for research focused on cancer therapies and vascular biology. PNU-145156E is instrumental in studies investigating the molecular mechanisms underlying tumor angiogenesis and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 154788-16-6 |
| Applications | Angiogenesis Inhibitor |
| Formula | C45H36N10Na4O17S4 |
| Molecular Weight | 1209.04 |
| Synonyms | FCE26644 |
| SMILES | O=C(NC1=CN(C)C(C(NC2=CN(C)C(C(NC3=CC4=C(S(=O)(O[Na])=O)C=C(S(=O)(O[Na])=O)C=C4C=C3)=O)=C2)=O)=C1)NC5=CN(C)C(C(NC6=CN(C)C(C(NC7=CC8=C(S(=O)(O[Na])=O)C=C(S(=O)(O[Na])=O)C=C8C=C7)=O)=C6)=O)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.