PNU-292137 is a potent inhibitor of Cyclin-Dependent Kinase 2 (CDK2), with IC50 values of 37 nM for the CDK2/cyclin A complex and 92 nM for the CDK2/cyclin E complex. This compound interacts with the hydrophobic pocket located within the ATP binding site of CDK2, effectively hindering tumor cell proliferation in human colon and prostate cancer cell lines. Additionally, PNU-292137 demonstrates significant antitumor activity in vivo, evidenced by a tumor growth inhibition greater than 50% in mouse xenograft models, making it a valuable tool for cancer research.
PNU-292137 is a potent inhibitor of Cyclin-Dependent Kinase 2 (CDK2), with IC50 values of 37 nM for the CDK2/cyclin A complex and 92 nM for the CDK2/cyclin E complex. This compound interacts with the hydrophobic pocket located within the ATP binding site of CDK2, effectively hindering tumor cell proliferation in human colon and prostate cancer cell lines. Additionally, PNU-292137 demonstrates significant antitumor activity in vivo, evidenced by a tumor growth inhibition greater than 50% in mouse xenograft models, making it a valuable tool for cancer research.
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