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Polθ-IN-1-d3

Polθ Inhibitor

Polθ-IN-1-d3 is a deuterated inhibitor of DNA polymerase theta (Polθ), specifically designed for research in cancer biology. This compound exhibits significant activity in interfering with Polθ's role in DNA repair mechanisms, making it a valuable tool for studying tumorigenesis and therapeutic resistance. Its application in cancer research may aid in elucidating the molecular pathways involved in DNA repair and identifying novel therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2598122-35-9
Applications	Polθ Inhibitor
Formula	C₁₉H₁₂D₃ClF₅N₃O₄
Molecular Weight	482.80
SMILES	[2H]C([2H])([2H])N(C1=C(C=C(C(Cl)=C1)F)F)C([C@H]2N(C3=CC(C(F)(F)F)=CC(C)=N3)C([C@H]([C@H]2O)O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.