Fig. 1 · Structure
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PolyQ aggregation inhibitor C2-8
Huntingtin Inhibitor
C2-8 is a potent inhibitor of polyglutamine (polyQ) aggregation, specifically targeting the pathogenic form of the huntingtin protein. It demonstrates significant inhibition with IC50 values of 25 μM for recombinant HDQ51 and 0.05 μM in PC12 cells. C2-8 has been shown to reduce polyQ aggregation in organotypic hippocampal slice cultures from R6/2 transgenic mice and mitigate neurodegeneration in a Drosophila model of Huntington's disease. In vivo studies indicate that C2-8 effectively decreases huntingtin aggregate size, alleviates neuronal atrophy, and enhances motor performance in the R6/2 transgenic mouse model.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 300670-16-0 |
| Applications | Huntingtin Inhibitor |
| Formula | C19H14Br2N2O3S |
| Molecular Weight | 510.20 |
| Synonyms | Polyglutamine Aggregation inhibitor III |
| SMILES | O=C(NC1=CC=C(Br)C=C1)C2=CC=CC(S(=O)(NC3=CC=C(Br)C=C3)=O)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.