Fig. 1 · Structure
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Pomalidomide 4'-alkylC5-acid
E3 Ligase Ligand-Linker Conjugates
Pomalidomide 4'-alkylC5-acid functions as an E3 ligase ligand-linker conjugate targeting cereblon (CRBN). This compound demonstrates significant potential in the development of PROTACs (Proteolysis-targeting chimeras), facilitating targeted protein degradation in cellular systems. It is a valuable tool for enhancing research in protein homeostasis and therapeutic applications in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2225940-49-6 |
| Applications | E3 Ligase Ligand-Linker Conjugates |
| Formula | C19H21N3O6 |
| Molecular Weight | 387.39 |
| SMILES | O=C(O)CCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.