Fig. 1 · Structure
Documents & Downloads
Pomalidomide-5-C6-NH2 hydrochloride
CRBN Ligand
Pomalidomide-5-C6-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide. This compound functions by facilitating the recruitment of CRBN proteins, making it an essential tool for the development of PROTAC (Proteolysis Targeting Chimeras) constructs. Its ability to form linkages with target proteins through a linker enhances its utility in targeted protein degradation research, paving the way for innovative therapeutic strategies in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 3007650-02-1 |
| Applications | CRBN Ligand |
| Formula | C19H25ClN4O4 |
| Molecular Weight | 408.88 |
| SMILES | O=C1C(C=CC(NCCCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.