Fig. 1 · Structure
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Pomalidomide-5-O-CH3
Ligand for E3 Ligase
Pomalidomide-5-O-CH3 is a synthetic derivative of Pomalidomide designed as a ligand for cereblon (CRBN), an E3 ubiquitin ligase. This compound facilitates the recruitment of CRBN, enabling targeted protein degradation through PROTAC (proteolysis targeting chimeras) technology. Pomalidomide-5-O-CH3 is valuable for research in targeted therapy and ubiquitin-proteasome system studies, contributing to insights in cancer treatment and cellular regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1547163-02-9 |
| Applications | Ligand for E3 Ligase |
| Formula | C14H13N3O5 |
| Molecular Weight | 303.27 |
| SMILES | O=C1C2=CC=C(C(N)=C2C(N1C3C(NC(CC3)=O)=O)=O)OC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.