Fig. 1 · Structure
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Pomalidomide-6-O-CH3
Ligand for E3 Ligase
Pomalidomide-6-O-CH3 is a modified derivative of Pomalidomide that serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound plays a crucial role in the recruitment of CRBN, facilitating targeted protein degradation through the formation of PROTACs when linked to other protein ligands. Its application in the study of protein turnover and degradation pathways makes it a valuable tool in chemical biology and therapeutic research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1547163-08-5 |
| Applications | Ligand for E3 Ligase |
| Formula | C14H13N3O5 |
| Molecular Weight | 303.27 |
| SMILES | O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(N)=CC(OC)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.