Fig. 1 · Structure
Documents & Downloads
Pomalidomide-6-OH
Ligand for E3 Ligase
Pomalidomide-6-OH is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating targeted protein degradation through the proteolysis-targeting chimera (PROTAC) approach. This compound is instrumental in research applications focused on the selective modulation of protein levels within cellular contexts, contributing to studies in cancer and other diseases. Pomalidomide-6-OH serves as a valuable tool for investigating the biochemical pathways regulated by CRBN.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1547162-44-6 |
| Applications | Ligand for E3 Ligase |
| Formula | C13H11N3O5 |
| Molecular Weight | 289.24 |
| SMILES | O=C1NC(C(CC1)N2C(C3=C(C2=O)C(N)=CC(O)=C3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.