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Pomalidomide-C5-Dovitinib

Anti-cancer Agent

Pomalidomide-C5-Dovitinib is a PROTAC designed to target the degradation of the FLT3-ITD and KIT proteins through a ubiquitin-proteasome-dependent mechanism. This compound exhibits potent antiproliferative effects specifically against FLT3-ITD+ acute myeloid leukemia (AML) cells by effectively disrupting their downstream signaling pathways. Pomalidomide-C5-Dovitinib is valuable for research aimed at understanding and treating FLT3-ITD+ AML.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2732969-67-2
Applications	Anti-cancer Agent
Formula	C₃₉H₃₈FN₉O₆
Molecular Weight	747.77
SMILES	O=C1NC2=C(C(N)=C1C3=NC4=CC=C(N5CCN(CC5)C(CCCCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)C=C4N3)C(F)=CC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.