Fig. 1 · Structure
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POMHEX
ENO2 Inhibitor
POMHEX is a potent inhibitor of enolase 2 (ENO2), functioning as a cell-permeable pivaloyloxymethyl (POM) proagent of HEX. It demonstrates low-nanomolar potency in vitro against ENO1-deleted cell lines and effectively eradicates ENO1-deleted xenograft tumors in vivo. POMHEX serves as a valuable tool for investigating the role of ENO2 in glycolysis and its potential implications in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2004714-34-3 |
| Applications | ENO2 Inhibitor |
| Formula | C17H30NO9P |
| Molecular Weight | 423.40 |
| SMILES | O=P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)C1C(N(O)CCC1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.