Fig. 1 · Structure
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Ponatinib-d8
Stable Isotope
Ponatinib-d8 is a deuterated form of the multi-targeted kinase inhibitor Ponatinib, designed for use in stable isotope labeling studies. With high potency, Ponatinib selectively inhibits crucial kinases including Abl (IC50 = 0.37 nM), PDGFRα (1.1 nM), VEGFR2 (1.5 nM), FGFR1 (2.2 nM), and Src (5.4 nM). This reagent is particularly valuable in biochemical research aimed at elucidating kinase signaling pathways and evaluating therapeutic responses in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1562993-37-6 |
| Applications | Stable Isotope |
| Formula | C29H19D8F3N6O |
| Molecular Weight | 540.61 |
| Synonyms | AP24534-d8 |
| SMILES | O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.