Ponatinib-d8 is a deuterated form of the multi-targeted kinase inhibitor Ponatinib, designed for use in stable isotope labeling studies. With high potency, Ponatinib selectively inhibits crucial kinases including Abl (IC50 = 0.37 nM), PDGFRα (1.1 nM), VEGFR2 (1.5 nM), FGFR1 (2.2 nM), and Src (5.4 nM). This reagent is particularly valuable in biochemical research aimed at elucidating kinase signaling pathways and evaluating therapeutic responses in cancer research.
Ponatinib-d8 is a deuterated form of the multi-targeted kinase inhibitor Ponatinib, designed for use in stable isotope labeling studies. With high potency, Ponatinib selectively inhibits crucial kinases including Abl (IC50 = 0.37 nM), PDGFRα (1.1 nM), VEGFR2 (1.5 nM), FGFR1 (2.2 nM), and Src (5.4 nM). This reagent is particularly valuable in biochemical research aimed at elucidating kinase signaling pathways and evaluating therapeutic responses in cancer research.
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