Fig. 1 · Structure
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Porfiromycin
Alkylating Agent
Porfiromycin, a bioreductive alkylating agent, exerts preferential cytotoxic effects on hypoxic tumor cells compared to aerobic cells. This compound works by forming DNA cross-links, leading to cellular damage and apoptosis in tumor environments with limited oxygen availability. Porfiromycin is primarily utilized in cancer research for its potential to identify and target hypoxic regions within tumors, thereby improving therapeutic strategies for hypoxic cancers.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 801-52-5 |
| Applications | Alkylating Agent |
| Formula | C16H20N4O5 |
| Molecular Weight | 348.35 |
| Synonyms | N-Methylmitomycin C; NSC-56410; U-14743 |
| SMILES | CO[C@]12N(C[C@@]3([H])[C@]2([H])N3C)C4=C(C(C(N)=C(C4=O)C)=O)[C@H]1COC(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.