Fig. 1 · Structure
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POSH-IN-2
Mitochondrial Division iInhibitor
POSH-IN-2 is a potent inhibitor of mitochondrial division, specifically targeting dynamin-related protein 1 (DRP1). This compound effectively prevents mitochondrial fragmentation caused by cellular stressors and genetic mitochondrial defects. By covalently binding to the C367 residue of DRP1, POSH-IN-2 disrupts its interactions with various receptors, making it a valuable tool for research into mitochondrial dynamics and related pathophysiological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 348145-43-7 |
| Applications | Mitochondrial Division iInhibitor |
| Formula | C22H16N2O2 |
| Molecular Weight | 340.37 |
| SMILES | O=C(C1=CC=C(C(/C=C/C2=CC=CN=C2)=O)C=C1)/C=C/C3=CC=CN=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.