Fig. 1 · Structure

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Potassium 1,2-naphthoquinone-4-sulphonate

6PGDH Inhibitor

Potassium 1,2-naphthoquinone-4-sulphonate is a selective inhibitor of 6-phosphogluconate dehydrogenase (6PGDH), exhibiting an IC50 value of 53 μM. This compound is particularly useful in research related to human African trypanosomiasis, enabling studies on metabolic pathways and potential therapeutic targets. Its role as a 6PGDH inhibitor underscores its significance in exploring the biochemical mechanisms of trypanosomiasis and related conditions.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 5908-27-0
Applications 6PGDH Inhibitor
Formula C10H5KO5S
Molecular Weight 276.31
SMILES
O=C1C=C(S(=O)(O[K])=O)C2=CC=CC=C2C1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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