Poterepatide

Catalog No.: A60642
GLP-1R/GIPR Agonist
Poterepatide is a long-acting dual agonist of the GLP-1 receptor (GLP-1R) and glucose-dependent insulinotropic peptide receptor (GIPR). It demonstrates significant activity at both receptor sites, making it a valuable tool in the investigation of metabolic disorders. Poterepatide is primarily utilized in research focused on obesity and type 2 diabetes, offering insights into potential therapeutic strategies for these conditions.
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50mg
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPoterepatide is a long-acting dual agonist of the GLP-1 receptor (GLP-1R) and glucose-dependent insulinotropic peptide receptor (GIPR). It demonstrates significant activity at both receptor sites, making it a valuable tool in the investigation of metabolic disorders. Poterepatide is primarily utilized in research focused on obesity and type 2 diabetes, offering insights into potential therapeutic strategies for these conditions.
Product Information
Catalog NumA60642
FormulaC243H382N52O73
Molecular Weight5199.94
CAS Number3058127-20-8
SequenceTyr-{Aib}-Glu-Gly-Thr-{Phe(αMe)}-Thr-Ser-Asp-Tyr-{Aib}-Ile-{Aib}-Leu-Asp-Lys-Gln-Ala-Gln-Ala-Glu-Phe-Val-{K(AEEA-AEEA-AEEA-{γGlu}-C22 diacid)}-Trp-Leu-Leu-Lys-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Lys
Sequence shorteningY-{Aib}-EGT-{Phe(αMe)}-TSDY-{Aib}-I-{Aib}-LDKQAQAEFV-{K(AEEA-AEEA-AEEA-{γGlu}-C22 diacid)}-WLLKGGPSSGAPPPSK
SynonymsHDM1005
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