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PP487

tyrosine kinase/PI(3)Ks

PP487 is a dual inhibitor targeting tyrosine kinases and phosphoinositide 3-kinases (PI(3)Ks), demonstrating potent inhibitory activity with IC50 values of 0.017 μM against DNA-PK, 0.072 μM against mTOR, 0.004 μM against Hck, 0.01 μM against Src, 0.55 μM against EGFR, 0.22 μM against EphB4, and < 0.01 μM against PDGFR. This compound is valuable for cancer research and can aid in the investigation of signaling pathways involved in tumorigenesis and therapeutic resistance.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1092787-12-6
Applications	tyrosine kinase/PI(3)Ks
Formula	C₁₄H₁₄BrN₅O
Molecular Weight	348.20
SMILES	BrC1=C(O)C=C(C2=NN(C(C)C)C3=C2C(N)=NC=N3)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.