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PPA-037

CDK12 Inhibitor

PPA-037 is a potent and selective inhibitor of cyclin-dependent kinase 12 (CDK12) with oral bioavailability. By inducing the degradation of cyclin K, PPA-037 enhances antiproliferative effects on various tumor cells. This compound holds significant potential for cancer research applications focused on targeting CDK12-related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2883700-83-0
Applications	CDK12 Inhibitor
Formula	C₂₅H₂₇N₇
Molecular Weight	425.53
SMILES	C1(CNC2=CC(N[C@H]3CCNC3)=NC4=C(C5CC5)C=NN24)=CC=C(C6=CC=CC=N6)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.