PPARα/δ Agonist 3 is a selective agonist targeting peroxisome proliferator-activated receptors (PPARs), specifically activating PPARα, PPARδ, and PPARγ with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. This compound demonstrates significant anticholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA. It is useful for studying the role of PPAR activation in lipid metabolism and the pathophysiology of liver diseases.
PPARα/δ Agonist 3 is a selective agonist targeting peroxisome proliferator-activated receptors (PPARs), specifically activating PPARα, PPARδ, and PPARγ with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. This compound demonstrates significant anticholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA. It is useful for studying the role of PPAR activation in lipid metabolism and the pathophysiology of liver diseases.
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