Fig. 1 · Structure
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PPI-2458
MetAP-2 Inhibitor
PPI-2458 is a selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). This compound demonstrates potent activity in inhibiting protein processing and is useful in studying diseases associated with MetAP-2 dysfunction, including conditions such as arthritis and lymphoma. Researchers may employ PPI-2458 to explore its therapeutic potential in these areas and to investigate the biological pathways regulated by MetAP-2.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 431077-35-9 |
| Applications | MetAP-2 Inhibitor |
| Formula | C22H36N2O6 |
| Molecular Weight | 424.53 |
| SMILES | O=C(O[C@H](CC1)[C@@H](OC)[C@H]([C@@]2(C)O[C@@H]2C/C=C(C)\C)[C@]31CO3)N[C@@H](C(N)=O)C(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.