Fig. 1 · Structure
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PPNDS tetrasodium
Meprin β Inhibitor
PPNDS tetrasodium is a selective and competitive inhibitor of meprin β, demonstrating an IC50 of 80 nM and a Ki of 8 nM. In addition, it exhibits inhibitory effects on ADAM10 with an IC50 of 1.2 μM and serves as a P2X1 receptor antagonist. This compound also acts as an agonist for the ATP receptor found in Paramecium and effectively inhibits viral polymerases. PPNDS tetrasodium is valuable in studies related to infections and cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1021868-77-8 |
| Applications | Meprin β Inhibitor |
| Formula | C18H11N4Na4O14PS2 |
| Molecular Weight | 694.36 |
| SMILES | O=CC1=C(C(C)=NC(/N=N/C2=CC(S(=O)(O[Na])=O)=C(C=C([N+]([O-])=O)C=C3S(=O)(O[Na])=O)C3=C2)=C1COP(O[Na])(O[Na])=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.