Fig. 1 · Structure
Documents & Downloads
PR-104A
DNA Cross-linking Agent
PR-104A is a hypoxia-selective DNA cross-linking agent that operates through the selective generation of DNA damage under low oxygen conditions. This compound exhibits significant antitumor activity and serves as a potent cytotoxin. Metabolized by the 1-electron NADPH:cytochrome P450 oxidoreductase, PR-104A is particularly useful in research focused on relapsed or refractory T-lineage acute lymphoblastic leukemia (T-ALL), providing insights into therapeutic strategies for challenging cancer types.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 680199-06-8 |
| Applications | DNA Cross-linking Agent |
| Formula | C14H19BrN4O9S |
| Molecular Weight | 499.29 |
| Synonyms | SN 27858 |
| SMILES | BrCCN(CCOS(=O)(C)=O)C1=C(C(NCCO)=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.