Fig. 1 · Structure
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Pradefovir
Cytochrome P450
Pradefovir is a substrate for cytochrome P450, specifically CYP3A4, in liver microsomes. It is metabolized into 9-(2-phosphonylmethoxyethyl)adenine (PMEA) with a Km value of 60 μM. This compound is relevant for studies involving liver pharmacokinetics and the metabolic pathways of nucleoside analogs, offering insights into drug metabolism and efficacy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 625095-60-5 |
| Applications | Cytochrome P450 |
| Formula | C17H19ClN5O4P |
| Molecular Weight | 423.79 |
| SMILES | NC1=C2N=CN(CCOC[P@]3(OCC[C@@H](C4=CC=CC(Cl)=C4)O3)=O)C2=NC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.